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Particular attention is focused on postnatal/adult neurogenesis, an issue which has been deeply investigated in the last decade as an example of persisting structural plasticity with potential implications for brain repair strategies.
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acetylneuraminic acid whose major carrier in vertebrates is the neural cell adhesion molecule (NCAM).
PSA serves as a potent negative regulator of cell interactions via its unusual biophysical properties.
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After birth, they undergo morphological and molecular modifications allowing structural plasticity to adapt to the non-permissive environment of the mature nervous tissue, that are paralled by changes in the expression of PSA-NCAM.